Tripeptide-1 / Copper Peptide
PreclinicalCopper peptide complex
Research material. Not for human or animal consumption.
Research overview
Tripeptide-1 is glycyl-histidyl-lysine (GHK), a tripeptide first isolated from human plasma in 1973 by Loren Pickart. It binds copper(II) with high affinity to form GHK-Cu, the form most often studied. Cell and animal work links GHK-Cu to fibroblast activity, collagen and glycosaminoglycan synthesis and wound contraction, and it is widely used in topical cosmetic formulations. The free peptide and the copper complex are different materials and should not be treated as interchangeable.
Laboratory, computational, ex vivo or animal model research is the main evidence base.
Questions about Tripeptide-1 / Copper Peptide
PRODUCT QUESTIONSWhat is Tripeptide-1 / Copper Peptide?
Tripeptide 1 is the sequence glycine, histidine, lysine. When bound to copper(II) it forms GHK Cu, a blue complex in which copper is held by the histidine ring, the glycine amino group and a backbone nitrogen.
What research has been published on Tripeptide-1 / Copper Peptide?
Research on GHK Cu covers fibroblast and keratinocyte cultures, collagen and matrix protein expression, and wound models in rodents. Gene expression analyses suggested broad effects on tissue remodelling genes. Human evidence mainly comes from cosmetic studies of finished topical products, so findings on skin appearance should not be read as therapeutic outcomes.
What batch documentation should accompany Tripeptide-1 / Copper Peptide?
Tripeptide-1 / Copper Peptide: Ask for the COA and analytical reports for the batch being quoted. The certificate should state whether the material is free GHK or the copper complex, give quantified metal content and the copper to peptide ratio, and include HPLC purity and mass spectrometry for the peptide.
How should Tripeptide-1 / Copper Peptide storage conditions be assessed?
Store the dry powder sealed and refrigerated, protected from light and humidity. In solution the copper complex is sensitive to pH and to chelating agents such as EDTA, which can strip the copper, so check compatibility with buffers before use.