Acetyl Tetrapeptide-15
Early humanSynthetic tetrapeptide
Research material. Not for human or animal consumption.
Research overview
Acetyl Tetrapeptide-15 is a synthetic cosmetic peptide modelled on endomorphin-2, an endogenous opioid peptide that acts on mu-opioid receptors found on cutaneous sensory nerve endings. It was developed to raise the threshold at which sensitive skin reacts to heat, chemical or mechanical triggers. Most published evidence comes from supplier-sponsored nerve cell assays and a small split-face study that used capsaicin-induced discomfort as the test endpoint.
Limited, exploratory, early phase or small human studies have been identified.
Questions about Acetyl Tetrapeptide-15
PRODUCT QUESTIONSWhat is Acetyl Tetrapeptide-15?
Acetyl Tetrapeptide-15 is a four residue synthetic peptide with an acetylated N terminus, designed after the endogenous opioid endomorphin 2. Its INCI name describes a cosmetic ingredient rather than a defined pharmaceutical substance.
What research has been published on Acetyl Tetrapeptide-15?
Studies concentrate on sensitive skin. Supplier sponsored work used cultured sensory neurons to measure reduced release of the neuropeptide CGRP, and a 20 participant split face, single blind study tested whether a topical formulation reduced stinging after capsaicin challenge. Independent replication remains limited.
What batch documentation should accompany Acetyl Tetrapeptide-15?
Acetyl Tetrapeptide-15: Ask for the COA and analytical reports for the batch being quoted. Expect mass spectrometry confirming the acetylated tetrapeptide, HPLC purity with the method stated, and the residual solvent and water content that affect cosmetic formulation work.
How should Acetyl Tetrapeptide-15 storage conditions be assessed?
Acetyl Tetrapeptide-15 powder is relatively stable when dry. Store it sealed at 2°C to 8°C, or at −20°C for long holding periods, protected from moisture. Aqueous cosmetic bases should be tested for stability at the intended pH before use.