Palmitoyl Pentapeptide-4 / Palmitoyl Pentapeptide-3
Early humanLipidated pentapeptide analogue(s)
Research material. Not for human or animal consumption.
Research overview
Palmitoyl Pentapeptide-4, sold as Matrixyl and formerly labelled Palmitoyl Pentapeptide-3, is the lipopeptide Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS). Its peptide portion is a fragment of the type I procollagen propeptide, and the palmitic acid tail was added to improve skin penetration. Cell work reported increased collagen and fibronectin synthesis in fibroblasts. Human evidence includes a 2005 double-blind split-face moisturiser study and a small 2023 randomised topical study, both reporting exploratory cosmetic signals.
Limited, exploratory, early phase or small human studies have been identified.
Questions about Palmitoyl Pentapeptide-4 / Palmitoyl Pentapeptide-3
PRODUCT QUESTIONSWhat is Palmitoyl Pentapeptide-4 / Palmitoyl Pentapeptide-3?
This listing covers palmitoylated KTTKS, a five residue peptide derived from type I procollagen and joined to palmitic acid. Palmitoyl pentapeptide 3 is an older INCI name for the same lipopeptide, which is now listed as palmitoyl pentapeptide 4.
What research has been published on Palmitoyl Pentapeptide-4 / Palmitoyl Pentapeptide-3?
Fibroblast cultures exposed to KTTKS showed increased synthesis of collagen types I and III and fibronectin, which led to its use as a matrikine in skin care. Human data are small: a 2005 split face moisturiser trial and a 21 participant randomised study in 2023 reported changes in wrinkle and texture measures rather than therapeutic outcomes.
What batch documentation should accompany Palmitoyl Pentapeptide-4 / Palmitoyl Pentapeptide-3?
Palmitoyl Pentapeptide-4 / Palmitoyl Pentapeptide-3: Ask for the COA and analytical reports for the batch being quoted. The palmitoyl group makes the peptide poorly water soluble, so check that the HPLC method uses a suitable organic gradient, that mass spectrometry confirms the acylated mass, and that free KTTKS is reported as an impurity.
How should Palmitoyl Pentapeptide-4 / Palmitoyl Pentapeptide-3 storage conditions be assessed?
Keep this lipopeptide dry and sealed at 2°C to 8°C, or frozen for long storage, away from light. Its fatty acid chain encourages it to stick to plastics and form micelles, so solutions are usually prepared in glass with a cosolvent.
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