Tetracosactide Acetate
Synthetic ACTH fragment peptide (1 24)
Research material. Not for human or animal consumption.
Research overview
Tetracosactide, also called cosyntropin and sold as Synacthen, is a synthetic peptide matching the first 24 amino acids of adrenocorticotropic hormone (ACTH). These residues carry ACTH's full activity at the melanocortin-2 receptor in the adrenal cortex, which drives cortisol production. Its established use is the short Synacthen test, in which blood cortisol is measured before and after an injection to assess adrenal reserve and investigate adrenal insufficiency.
An authorisation applies to at least one defined finished product in a stated jurisdiction; it does not apply automatically to this catalogue material.
Questions about Tetracosactide Acetate
PRODUCT QUESTIONSWhat is Tetracosactide Acetate?
Tetracosactide Acetate is the acetate salt of the 24 residue N terminal fragment of human ACTH. Positions 25 to 39 of ACTH are not needed for receptor activation and are omitted.
What research has been published on Tetracosactide Acetate?
Most research concerns diagnostic testing: comparing standard and low dose tests, choosing cortisol cut offs as assay methods change, and diagnosing adrenal insufficiency in critical illness. Long acting depot forms were used therapeutically in some countries. Laboratory work uses it to study MC2 receptor signalling and steroid production.
What batch documentation should accompany Tetracosactide Acetate?
Tetracosactide Acetate: Ask for the COA and analytical reports for the batch being quoted. Ask for mass spectrometry, HPLC purity with oxidised methionine reported, peptide content and, for functional work, a bioassay or reference to a recognised standard.
How should Tetracosactide Acetate storage conditions be assessed?
Store Tetracosactide Acetate at 2°C to 8°C, protected from light. Its methionine residue oxidises, which reduces potency, so keep vials sealed and avoid prolonged exposure to air.