Ziconotide
Conopeptide N type calcium channel blocker
Research material. Not for human or animal consumption.
Research overview
Ziconotide (Prialt) is a synthetic version of ω-conotoxin MVIIA, a 25-amino-acid peptide from the venom of the fish-hunting cone snail Conus magus. It blocks N-type (Cav2.2) voltage-gated calcium channels on pain-signalling nerves in the spinal cord, stopping neurotransmitter release. Because it does not cross into the nervous system from the blood, it is given by intrathecal infusion. It is authorised for severe chronic pain, but psychiatric and neurological side effects need careful monitoring.
An authorisation applies to at least one defined finished product in a stated jurisdiction; it does not apply automatically to this catalogue material.
Questions about Ziconotide
PRODUCT QUESTIONSWhat is Ziconotide?
Ziconotide is a 25 residue peptide held in a tight knotted shape by three disulfide bonds, an arrangement known as an inhibitor cystine knot. It is identical to the natural cone snail toxin.
What research has been published on Ziconotide?
Controlled trials of intrathecal ziconotide in severe chronic pain, including cancer and AIDS related pain, measured pain scores and adverse events such as confusion, dizziness and mood changes. Preclinical research uses it as a standard blocker of N type calcium channels in nerve signalling and pain models.
What batch documentation should accompany Ziconotide?
Ziconotide: Ask for the COA and analytical reports for the batch being quoted. Correct folding of the three disulfide bonds is essential, so ask for mass spectrometry, HPLC purity that separates misfolded isomers, and confirmation of the disulfide pattern.
How should Ziconotide storage conditions be assessed?
Store Ziconotide refrigerated at 2°C to 8°C, protected from light. Its methionine can oxidise and it can be lost by adsorption, so use low binding containers and avoid freezing solutions repeatedly.