Selank
Early humanSynthetic tuftsin derived peptide analogue
Research material. Not for human or animal consumption.
Research overview
Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, developed at the Institute of Molecular Genetics in Moscow. It consists of tuftsin, a natural immunomodulatory tetrapeptide from immunoglobulin G, extended with a Pro-Gly-Pro tail that slows breakdown. Selank is registered in Russia as a nasal spray for anxiety. Evidence includes small Russian comparative studies in generalised anxiety and neurasthenia, plus animal research on GABA receptor modulation, enkephalin breakdown and gene expression in the brain.
Limited, exploratory, early phase or small human studies have been identified.
Questions about Selank
PRODUCT QUESTIONSWhat is Selank?
Selank is a seven residue peptide made of the tuftsin sequence, threonine, lysine, proline, arginine, followed by proline, glycine, proline. The extra tripeptide protects it from rapid enzymatic breakdown.
What research has been published on Selank?
Human data come from small Russian studies comparing Selank with benzodiazepines in anxiety and neurasthenia, reporting similar anxiety score changes without sedation, though trial design limits conclusions. Animal studies describe effects on GABA A receptor related signalling, enkephalin degrading enzymes and the expression of genes linked to inflammation and neurotransmission.
What batch documentation should accompany Selank?
Selank: Ask for the COA and analytical reports for the batch being quoted. Expect mass spectrometry and HPLC purity, with attention to the shortened tuftsin sequence, a likely synthesis impurity, and an acetate content figure if supplied as the salt.
How should Selank storage conditions be assessed?
Store lyophilised Selank sealed at −20°C, or at 2°C to 8°C for shorter periods, away from light. Its proline rich tail makes it fairly stable, but solutions should still be kept cold and used within days.