Beta-Neoendorphin
PreclinicalEndogenous opioid peptide
Research material. Not for human or animal consumption.
Research overview
Beta-neoendorphin, Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro, is a nine-amino-acid opioid peptide cut from prodynorphin, the same precursor that produces dynorphin A and B. Like them, it begins with the Leu-enkephalin sequence and acts at kappa-opioid receptors, with activity at other opioid receptors too. It is less studied than the dynorphins, and research is mostly biochemical and preclinical, including a report that it speeds migration of skin keratinocytes in wound-healing models.
Laboratory, computational, ex vivo or animal model research is the main evidence base.
Questions about Beta-Neoendorphin
PRODUCT QUESTIONSWhat is Beta-Neoendorphin?
Beta Neoendorphin is a nine residue opioid peptide derived from prodynorphin. Its first five residues are identical to leucine enkephalin, followed by arginine, lysine, tyrosine and proline.
What research has been published on Beta-Neoendorphin?
Research covers opioid receptor binding, prodynorphin processing in the brain and spinal cord, and peptide measurement methods. Cell studies reported that beta neoendorphin accelerated keratinocyte migration through MAPK signalling. Human data are limited to tissue measurements.
What batch documentation should accompany Beta-Neoendorphin?
Beta-Neoendorphin: Ask for the COA and analytical reports for the batch being quoted. Ask for mass spectrometry distinguishing it from alpha neoendorphin, which has one more residue, plus HPLC purity and peptide content.
How should Beta-Neoendorphin storage conditions be assessed?
Store Beta Neoendorphin lyophilised at −20°C, protected from light and moisture. Its basic residues make it sticky, so use low binding tubes for dilute solutions.