Antide / Vapreotide Acetate
Early humanMixed peptide entries (GnRH antagonist; somatostatin analogue)
Research material. Not for human or animal consumption.
Research overview
This listing names two unrelated peptides, so researchers should confirm which one a batch contains. Antide (iturelix) is a decapeptide GnRH antagonist developed in the late 1980s and studied mainly in primates and rodents for suppressing reproductive hormones. Vapreotide (RC-160) is an octapeptide somatostatin analogue that reached clinical trials, most notably for acute oesophageal variceal bleeding in cirrhosis. Their mechanisms, evidence and analytical requirements are separate.
Limited, exploratory, early phase or small human studies have been identified.
Questions about Antide / Vapreotide Acetate
PRODUCT QUESTIONSWhat is Antide / Vapreotide Acetate?
Antide is a synthetic GnRH antagonist decapeptide rich in unnatural amino acids, also known as iturelix. Vapreotide is a cyclic octapeptide somatostatin analogue held together by a disulfide bond. The listing covers both names but they are different molecules.
What research has been published on Antide / Vapreotide Acetate?
Antide research is mostly preclinical and focuses on rapid suppression of gonadotropins and sex steroids in primates and rodents. Vapreotide was tested in human trials of acute variceal bleeding, where it was given alongside endoscopic treatment, and in studies of gastrointestinal and endocrine hormone suppression.
What batch documentation should accompany Antide / Vapreotide Acetate?
Antide / Vapreotide Acetate: Ask for the COA and analytical reports for the batch being quoted. The certificate must state which of the two peptides the batch contains, with mass spectrometry, HPLC purity and, for vapreotide, evidence that the disulfide bond is intact.
How should Antide / Vapreotide Acetate storage conditions be assessed?
Whichever peptide is supplied, store the lyophilised solid at −20°C, dry and protected from light. Vapreotide's disulfide bond favours slightly acidic, cold solutions, while Antide is poorly soluble in water and may need a cosolvent.