Semaglutide
Synthetic glucagon like peptide 1 receptor agonist peptide
Research material. Not for human or animal consumption.
Research overview
Semaglutide is a GLP-1 receptor agonist developed by Novo Nordisk. It is built on the [Arg34]GLP-1 backbone with two key changes: aminoisobutyric acid at position 8 to block DPP-4 breakdown, and a C18 fatty diacid on lysine 26 that binds albumin, giving a half-life of about a week. Large randomised programmes, including SUSTAIN in type 2 diabetes, STEP in chronic weight management and SELECT in cardiovascular outcomes, underpin authorised products such as Ozempic, Wegovy and the oral tablet Rybelsus.
An authorisation applies to at least one defined finished product in a stated jurisdiction; it does not apply automatically to this catalogue material.
Questions about Semaglutide
PRODUCT QUESTIONSWhat is Semaglutide?
Semaglutide is a synthetic acylated glucagon like peptide 1 receptor agonist peptide widely used in metabolic, diabetes and obesity research.
What research has been published on Semaglutide?
Semaglutide is a long acting glucagon like peptide 1 receptor agonist and one of the most extensively trialled peptide medicines. Major randomised programmes have studied defined semaglutide products in type 2 diabetes, chronic weight management and cardiovascular outcomes, reporting indication specific glycaemic, weight and cardiovascular findings. Authorisation depends on the named product, formulation, dose, country and label; the clinical evidence does not establish equivalence or authorisation for a catalogue material.
What batch documentation should accompany Semaglutide?
Semaglutide: Ask for the COA and analytical reports for the batch being quoted. Ask for intact mass confirming the C18 diacid side chain, HPLC purity that separates the unacylated backbone and related impurities, peptide content and the salt or counterion form.
How should Semaglutide storage conditions be assessed?
Semaglutide is a lipidated peptide that self associates in solution. Store dry material at −20°C away from light, refrigerate solutions at 2°C to 8°C, and avoid freezing solutions or shaking them vigorously.
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