Retatrutide
Late stageSynthetic multireceptor peptide agonist
Research material. Not for human or animal consumption.
Research overview
Retatrutide (LY3437943) is an investigational once-weekly peptide from Eli Lilly that activates three hormone receptors: GIP, GLP-1 and glucagon. Adding glucagon receptor activity is intended to raise energy expenditure and reduce liver fat on top of the appetite effects of GLP-1 and GIP. A Phase 2 obesity trial published in 2023 reported an average weight reduction of about 24% at 48 weeks at the highest dose. The TRIUMPH Phase 3 programme covers obesity, type 2 diabetes, sleep apnoea, knee osteoarthritis and cardiovascular and kidney outcomes. It is not approved anywhere.
Substantial controlled clinical research or late stage development has been identified; this is not a product authorisation claim.
Questions about Retatrutide
PRODUCT QUESTIONSWhat is Retatrutide?
Retatrutide is a synthetic investigational multireceptor peptide agonist referenced in obesity research programmes for clinical development.
What research has been published on Retatrutide?
Retatrutide is an investigational triple hormone receptor agonist acting at GIP, glucagon like peptide 1 and glucagon receptors. Its Phase 3 programme spans chronic weight management, type 2 diabetes, obstructive sleep apnoea, knee osteoarthritis pain, cardiovascular and kidney outcomes, chronic low back pain and metabolic dysfunction associated steatotic liver disease. It remains investigational and is not presented here as authorised for human use.
What batch documentation should accompany Retatrutide?
Retatrutide: Ask for the COA and analytical reports for the batch being quoted. As a lipidated peptide containing unnatural amino acids, retatrutide needs mass spectrometry confirming the fatty diacid side chain, HPLC purity that resolves the unacylated peptide, and stated peptide content.
How should Retatrutide storage conditions be assessed?
Retatrutide: Storage depends on the supplied form. Keep the dry/lyophilised versus solution form distinction clear: store dry material at −20°C away from light, and refrigerate solutions at 2°C to 8°C. Its fatty acid chain encourages self association, so avoid repeated freeze and thaw cycles.
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