Exenatide Acetate
Synthetic exendin peptide (glucagon like peptide 1 receptor agonist)
Research material. Not for human or animal consumption.
Research overview
Exenatide is synthetic exendin-4, a 39-amino-acid peptide first found in the saliva of the Gila monster. It shares about half its sequence with human GLP-1 and activates the same receptor, but a glycine at position 2 makes it resistant to DPP-4, so it lasts hours rather than minutes. Approved as Byetta in 2005, it was the first GLP-1 receptor agonist medicine, later followed by the once-weekly microsphere formulation Bydureon. Trials covered type 2 diabetes, cardiovascular outcomes and, more recently, Parkinson's disease.
An authorisation applies to at least one defined finished product in a stated jurisdiction; it does not apply automatically to this catalogue material.
Questions about Exenatide Acetate
PRODUCT QUESTIONSWhat is Exenatide Acetate?
Exenatide Acetate is the acetate salt of a 39 residue peptide identical to exendin 4. Its C terminal tail, absent from human GLP 1, folds around the tryptophan and contributes to its stability.
What research has been published on Exenatide Acetate?
Randomised trials in type 2 diabetes measured HbA1c, weight and gastrointestinal side effects, and the EXSCEL trial assessed cardiovascular safety of weekly exenatide. Neurology studies explored it in Parkinson's disease, where a Phase 3 trial did not confirm earlier signals. It is widely used as a receptor agonist in laboratory research.
What batch documentation should accompany Exenatide Acetate?
Exenatide Acetate: Ask for the COA and analytical reports for the batch being quoted. Ask for mass spectrometry, HPLC purity with oxidised methionine and deamidated forms reported, peptide content and acetate content.
How should Exenatide Acetate storage conditions be assessed?
Store Exenatide Acetate at 2°C to 8°C, protected from light. It is more stable at mildly acidic pH, and solutions should not be frozen and thawed repeatedly.